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OpenAI announced the acquisition of San Francisco startup Orchestra Bio, which has developed AI agents to help pharmaceutical companies track the progress of drug development projects. Orchestra's team and platform will be integrated into OpenAI's life sciences product line Rosalind, aimed at biologists and chemists, with the transaction amount undisclosed. Orchestra was founded in the fall of 2022, with seed funding from Andreessen Horowitz, Definition Capital, Insight Partners, and 8VC, raising a total of approximately $20 million.According to OpenAI, a new drug can take up to 15 years from initial conception to approval in the United States, and the cost of bringing a single approved drug to market can exceed $2.6 billion, with less than 10% of candidate drugs entering human trials ultimately reaching the market. Orchestra's AI agents can automatically monitor tasks and flag issues, analyze how setbacks like production batch failures affect the overall development project, compile relevant information, and compare response strategies, ultimately allowing scientists and project leaders to make decisions.This acquisition follows competitor Anthropic's acquisition of Coefficient Bio for approximately $400 million in April, reflecting the competition among AI labs for new drug development workflows. In April, OpenAI launched the model GPT-Rosalind specifically designed for biology and drug discovery, available only to vetted U.S. corporate clients such as Amgen and Moderna, with the accompanying product Rosalind Workbench connecting the model to research tools and data.

According to Catcher Predict monitoring, in the market prediction event "Manchester City FC vs. AEK - More Markets" on Polymarket, the "Over" option of the sub-market "AEK 1st Half O/U 1.5" has experienced significant fluctuations in winning probability, soaring from 7.15% an hour ago to the current 28.25% (a fluctuation of 21.1%). Please note the impact of related breaking news.

Bitwise Chief Investment Officer Matt Hougan posted on the X platform that JPMorgan has included Bitcoin in its Long-Term Capital Markets Assumptions report, predicting that Bitcoin will be the highest returning asset over the next decade. The report provides an expected volatility for Bitcoin of 55%, while gold is at 17.2%.Hougan stated that the report comes with a lot of caveats and believes that Bitcoin is still in a maturation phase. He thinks the volatility assumptions provided in the report are too high and the return assumptions are too low.

According to Catcher Predict monitoring, in the market prediction event "Manchester City FC vs Ipswich Town FC More Markets" on Polymarket, the "Over" option for the sub-market "Manchester City FC Second Half Over/Under 2.5" has experienced significant fluctuations in winning probability, rising from 21% an hour ago to the current 36.5% (a fluctuation of 15.5%). Please note the impact of related breaking news.

According to Catcher Predict monitoring, in the Polymarket event "Manchester City vs Ipswich," the "Over" option in the sub-market "Second Half O/U 0.5" has experienced a sharp fluctuation in winning probability, dropping from 87.5% an hour ago to the current 70% (a fluctuation of 17.5%). Please note the impact of relevant breaking news.

According to Catcher Predict monitoring on-chain data, it predicts significant capital movements in the market Polymarket. A large whale invested $98,000 in the event "Manchester City FC vs. Paris Saint-Germain FC," specifically targeting "Manchester City FC." Based on the current transaction price, the latest corresponding winning probability for this target is 49%.

The surge in artificial intelligence infrastructure construction has driven up the prices of consumer technology products. The U.S. September CPI shows that the prices of computers and smart home assistants have increased by 9.7% year-on-year, marking the largest increase since 2006.The prices of software and accessories have risen by 28.4% year-on-year, raising concerns in the market about the rising costs of technology products.

According to Catcher Predict monitoring on-chain data, significant capital movements are predicted in the Polymarket market. A large whale invested $572,902.11 in a single bet on the event "Club Atlético de Madrid vs. Manchester United FC" for "Club Atlético de Madrid." Based on the current transaction price, the latest corresponding winning probability for this bet is 55%.

Binance stated that it was awarded the "Outstanding Contribution Award of the Community Chest Timely Rain Fund - Tai Po Fire Relief" at the Community Chest Annual Award Ceremony for the 2025/2026 fiscal year in Hong Kong, in recognition of its assistance and donations following the Tai Po fire.After the fire last year, Binance Group donated 10 million Hong Kong dollars to the Community Chest of Hong Kong for disaster relief and recovery efforts. Eowyn Chen, Chief Marketing Officer of Binance and representative of Binance Charity, accepted the award on behalf of the group.Binance claimed that since its establishment in 2018, Binance Charity has donated over 47 million US dollars, covering 87 countries and regions and benefiting more than 4.2 million people.

According to DeFiLlama data, Bitget has seen a net inflow of $675 million in the past 7 days, ranking first among centralized exchanges (CEX).

U.S. Treasury bonds resumed their decline on Wednesday, with the 30-year Treasury yield rising to its highest level since 2002, reaching 5.72%. The increase in oil prices has raised market concerns about inflation and interest rate hikes by the Federal Reserve.The yield on the UK 30-year government bond rose to 6%, while the yield on the French government bond of the same duration increased by 14 basis points. Mizuho International strategists stated that the market is affected by the rise in oil prices.

According to Reuters, the private valuation of crypto-friendly bank Revolut has reached $115 billion, making it the highest-valued startup in Europe, surpassing Barclays Bank in the UK and Société Générale in France.The company currently has 80 million customers, close to JPMorgan's 84 million, and higher than HSBC's 41 million. Revolut is applying for more market licenses to expand its business from Mexico to regions such as Australia.Revolut's pre-tax profit for 2025 is projected to be £1.7 billion, lower than Barclays Bank's £9 billion, but still maintaining rapid growth. Its revenue comes from various products such as payments, foreign exchange, and card subscriptions, rather than primarily relying on loans. By the end of 2025, Revolut's loan scale is only £2.2 billion, with a loan-to-deposit ratio of 6%, significantly lower than HSBC's 55% and Société Générale's 86%.Revolut still faces issues such as low revenue per customer, limited loan business scale, and insufficient usage of main accounts. In the U.S. market, the company holds a temporary license but will face more intense competition. Additionally, Revolut was previously fined in Lithuania for anti-money laundering deficiencies and mistakenly sent some customer data to hackers impersonating government investigators in September.

According to CoinDesk, Hester Peirce, a commissioner of the U.S. Securities and Exchange Commission (SEC), has completed her term today. She served in the agency for over 8 years and voted against the committee's decisions to take enforcement actions instead of creating industry-compliant rules multiple times, and she was an early proponent of the token safe harbor proposal.Hester Peirce previously led the Crypto Task Force and stated that the SEC's duty to protect investors includes using regulatory authority to provide regulatory boundaries for the rapidly expanding digital asset industry.

Cryptocurrency analyst @AxelAdlerJr stated that the buying pressure indicator in the Bitcoin futures market has risen to 4.9, the highest since August 19; the contract open interest has increased by nearly 9,000 BTC within 24 hours.This indicator reading means that the accumulated buying pressure over the past 12 hours is nearly five standard deviations higher than the average level of the past week. @AxelAdlerJr indicated that if the Bitcoin price remains above $85,000 while the upward momentum weakens, the upward trend is likely to continue; if the price falls below $83,000, the liquidation of newly established long positions may accelerate the decline.

Coinbase released a report indicating that the profit-taking scale of BTC has risen to its highest level of the year, while market demand has cooled. On September 22, holders realized a profit of 25,700 BTC in a single day, the highest daily level since 2026. At the same time, the unrealized profit margin for short-term traders rose to 33%, the highest since December 2024.Meanwhile, in the past 30 days, the apparent spot demand for BTC has decreased by 170,000 coins; the incremental speculative futures demand also dropped from 164,000 coins on September 14 to 16,000 coins on September 29.

According to Coinglass data, Bitcoin's return rate in the third quarter of 2026 reached 42.71%, setting the second highest record since 2013, only behind the 80.41% quarterly return rate achieved in the third quarter of 2017.

According to Coinglass data, Ethereum's return rate in the third quarter of 2026 reached 70.8%, setting the highest record since 2016, while the return rate in the third quarter of 2025 reached 66.55%, ranking second.

According to a report by The Block, CryptoQuant's research director Julio Moreno pointed out that Bitcoin's closing price last week was above the 365-day moving average, confirming the start of a new bull market. However, Moreno stated that after Bitcoin reached an eight-month high of $87,400, several indicators show that upward momentum is weakening, and a market correction may follow.The report noted that the on-chain unrealized profit margin for short-term traders has risen to 33%, the highest level since December 2024. Historically, when profit margins are at similar levels, it often prompts traders to take profits. Data shows that on September 22, Bitcoin holders realized profits of 25,700 BTC in a single day, setting a record for the highest daily profit since 2026; the altcoin market also showed signs of selling pressure. The seven-day cumulative number of altcoin transactions rose to 76,000, the highest level since October 17, 2025. Meanwhile, spot demand continues to shrink, and the growth of futures demand has significantly slowed.After Bitcoin previously reached an eight-month high of around $87,400, the upward momentum has shown signs of fatigue. Julio Moreno indicated that if a correction occurs, the 365-day moving average (around $80,000) will serve as the primary support, followed by the 200-day moving average (around $71,000) and the on-chain realized price for traders (around $67,000). Provided that the support levels hold, this correction is more likely to be a healthy consolidation in a young bull market rather than a trend reversal.

According to Catcher Predict monitoring, the "Eagles vs. Bears" event is currently among the hottest trades on the prediction market Polymarket, with a total pool size reaching 3.5668 million dollars. The option with the highest market consensus is "O/U 24.5," corresponding to a winning probability of approximately 92.5%.