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According to Gate market data, U.S. stocks opened with the Dow Jones down 0.1%, the S&P 500 index up 0.13%, and the Nasdaq up 0.3%. Biopharmaceutical company uniQure fell 39% due to its Huntington's disease gene therapy's 48-month data not reaching statistical significance.Summit Therapeutics rose 19.2% after AstraZeneca proposed to invest $2 billion in collaboration to develop cancer drugs.

a16z crypto stated that one of the core values of blockchain is "creating entirely new markets." By enabling permissionless issuance and global distribution, it breaks through the long-standing limitations of traditional financial markets, which are constrained by listing committees, legal frameworks, and geographic segmentation, allowing market supply to better match global potential demand.a16z crypto believes that almost all representative markets in the crypto industry benefit from this mechanism, ranging from perpetual contracts, spot DEX, prediction markets to lending, meme coins, NFTs, and the tokenization of real-world assets. Among these, perpetual contracts are the most direct manifestation of this trend. In July of this year, the on-chain RWA perpetual contract trading volume reached an annualized scale of $1.4 trillion, accounting for about half of Hyperliquid's trading volume. With mechanisms like HIP-3 and HIP-4 lowering market issuance thresholds, a16z crypto expects that on-chain markets will continue to expand into commodities, foreign exchange, indices, 24/7 stock exposure, as well as risk assets such as CPI, computing power, music, social trends, and sports, which previously lacked mature financial expressions.

Smart wearable device company OURA has postponed its IPO plans due to market uncertainty. The company previously planned to issue 50 million shares to raise up to $2.2 billion.OURA is currently profitable and is expected to see a 90% year-over-year revenue growth in fiscal year 2026. CEO Tom Hale stated that the company still has flexibility in choosing the timing.

During an interview with The Block at the Ondo event held in Seoul, South Korea, Ondo Perps CEO David Wells stated that offering perpetual contracts in the United States is a "huge opportunity," and that it is "reasonable" for Ondo to explore such expansion. He mentioned that everyone is paying attention to the U.S. because there are now more opportunities opening up that were previously impossible. However, he also noted that U.S. perpetual contract products will differ from existing products, with structures that vary from non-U.S. markets.Wells' remarks come as U.S. regulators are testing how perpetual contracts can enter the U.S. market with several companies. In August, Trump stated that the CFTC is "bringing Hyperliquid to the U.S. in a fully compliant and legal manner." Kraken's parent company, Payward, has announced plans to launch Hyperliquid's HIP-3 perpetual market for eligible U.S. customers through the CFTC-regulated Bitnomial Exchange and NinjaTrader Clearing. Coinbase has also applied to launch single-stock perpetual contracts in the U.S. Earlier this month, Ondo Finance submitted a letter to the SEC and CFTC arguing that U.S. stock perpetual contracts fall under the securities futures category as defined by the Commodity Futures Modernization Act of 2000.Wells indicated that while the U.S. version of perpetual contracts and its market structure may be similar, settlement and clearing would need to change to comply with U.S. regulations. He did not confirm any plans to enter the U.S. market, stating that the team has not "gone too far" in exploring the U.S. market.

According to Crypto in America, former CFTC Chairman Russ Behnam stated at the Georgetown University Financial Markets Quality Conference that as prediction markets experience explosive growth, Congress urgently needs to clarify the boundary between risk management and gambling, and related lawsuits may ultimately be submitted to the U.S. Supreme Court.Behnam also pointed out that after the Clarity Act failed to advance in the Senate, the CFTC's reliance on existing authority to regulate the spot market is akin to "patching things up with tape and paperclips," and regulators urgently need to establish more durable rules.

Spot gold rose slightly on Tuesday but remained trading below $4,200 per ounce. This followed a sell-off in the precious metals market triggered by U.S. Treasury yields rising to multi-decade highs and an increase in oil prices. IG analysts stated that gold only rebounded slightly due to market expectations that the Federal Reserve will maintain high interest rates for a longer period. Traders expect a 72.5% probability of a rate hike by the Federal Reserve in October. The market is focused on U.S. economic data, including the Consumer Confidence Index and job vacancy data.

ITC Crypto founder Benjamin Cowen published a post questioning the bearish outlook for Bitcoin in Q4, stating that from a technical perspective, the current market trend is favorable for bulls. Currently, the price of BTC is less than 1% away from the May peak, making it difficult to draw conclusions about the future market before entering the fourth quarter.

The crypto media The Block reported that there are 36 days until the U.S. midterm elections. The cumulative trading volume on the U.S. presidential election market on the prediction market platform Polymarket US has surpassed $545 million, making election-related markets one of the largest by trading volume on the platform.Traders currently assign a 91% probability to the Democratic Party winning the U.S. House of Representatives, up from 73% in May. The aforementioned trading volume and probability are both derived from the U.S. election-related markets on Polymarket US.

According to GMGN market data, the market capitalization of the ETH ecosystem token STOCKER briefly surpassed 6 million USD, currently reported at 5 million USD. According to the project introduction, STOCKER is positioned as an Ethereum ecosystem Meme/Stocks Launchpad, built on Ondo tokenized stocks, allowing users to create tokens and trade them in pairs with real stock tokens on the Ethereum chain.The price of this token is highly volatile and easily influenced by market sentiment and hot events, please be aware of trading risks.

According to GMGN market data, the market capitalization of the ETH ecosystem meme coin ZC (zipcoin) once surpassed 14 million USD, increasing over 21 times within the day, currently reported at 10.07 million USD.The narrative of ZC (zipcoin) originates from Vitalik's recently completed 32-chapter novel "Snowmoon." In the novel, the fictional country Veridia uses zipcoin as its currency and has designed mechanisms such as anonymous payments, burning tokens to release high-value information, high-cost signaling through "Doorstep Burn," and automatic taxation. The prices of meme coins are highly volatile and easily influenced by market sentiment and trending events, so please be aware of trading risks.

According to GMGN market data, the BSC ecosystem Meme coin "Chinese Can Fly" once surpassed a market value of 9 million USD, with a daily increase of over 13 times, currently reported at 8.1 million USD.Please note that the prices of Meme coins are highly volatile and can be easily influenced by market sentiment and trending events; please be aware of trading risks.

The Asian bond market is expected to follow the decline of U.S. Treasuries, as the U.S.-Iran standoff keeps oil prices high, exacerbating inflation concerns and increasing market bets on further interest rate hikes by the Federal Reserve.New Zealand government bonds opened lower, and Australian government bond futures may decline. The benchmark 10-year U.S. Treasury yield briefly rose by 11 basis points to 5.27%, reaching a new high in 19 years; the 30-year yield rose to 5.55%. Morgan Stanley analyst Chris Larkin stated that the market's focus may still be on interest rates and energy prices.

Renowned trader Bonk Guy stated that MARSCOIN's current trend is "very clean," and a significant rise is expected in the fourth quarter, also noting that its fundamentals are improving.The analyst believes that as BNB and BNB Chain's influence increases in this cycle, the "Musk + CZ" narrative for MARSCOIN is further strengthened. He pointed out that in the last cycle, SHIB and DOGE's market capitalizations respectively surpassed 40 billion and 80 billion dollars, while MARSCOIN this time will combine elements from Musk, Binance founder CZ, and space rocket company SPCX. Additionally, Binance has currently supported the related ecosystem through SPCX rewards and part of its own trading fees, suggesting that the market may be underestimating MARSCOIN's potential performance in the coming months.

Polymarket's Vice President Josh stated on platform X that the team is fully developing a complete Central Limit Order Book (CLOB) based on Rust, as the current CLOB is the root cause of most issues on the platform.According to the plan, the complete order lifecycle process, including trading, settlement, on-chain interaction, indexer, and engine notifications, will be completed in the testing environment in October; in November, all production traffic will be mirrored to the new trading cluster, and results will be compared with the existing system. At the same time, testing permissions will be opened to market makers, and the migration switch plan will be locked in, with two complete drills to be completed before the official switch.Josh also mentioned that if progress goes smoothly, the new system will be officially released, and the migration is expected to require little or no changes for market makers and developers.

CoinMarketCap announced on platform X that its Chief Product Officer David Salamon will assume the role of Chief Executive Officer, effective immediately. The former Chief Executive Officer Rush, after leading CoinMarketCap for five years, will transition to oversee the expansion of the group's new business line.CoinMarketCap stated that David Salamon joined CoinMarketCap in 2022 and during his tenure as Chief Product Officer, he led the development of CMC AI, which has surpassed 10 million users; he also spearheaded the reconstruction of CoinMarketCap's on-chain data infrastructure, with DexScan currently tracking 107 chains.

According to Gate market data, database company MongoDB announced that its President and CEO Chirantan "CJ" Desai has resigned, effective immediately, to take an executive position at Meta Platforms. As a result of this news, MongoDB's stock plummeted 15% in pre-market trading.

According to Crowdfund Insider, digital bank Revolut announced that it has received approval from the Central Bank of Argentina to acquire Banco Cetelem Argentina, a subsidiary of BNP Paribas.After the transaction is completed, the institution will be renamed Revolut Bank Argentina S.A.U. and will operate as a licensed bank, but initially will not offer products or services to the public. It will officially launch local operations after completing the remaining regulatory and operational requirements.Revolut stated that there are currently over 150,000 people on the waiting list for its operations in Argentina.

Japan's top foreign exchange official, Jun Mimura, stated that the market should recognize the "very clear" signals released last week by Japan and the United States regarding the yen issue, demonstrating a determination to take action against excessive declines.Japan's Finance Minister, Shunichi Suzuki, mentioned that U.S. President Trump expressed concerns about the weakness of the yen during a summit with Japanese Prime Minister, Sanae Takaichi. Jun Mimura emphasized that they will closely monitor market reactions and expressed dissatisfaction and unease regarding the recent yen trends.

JackYi (@Jackyi_ld) analyzed that this round of BTC pullback closely aligns with its prediction made 20 days ago, when it had already warned that BTC would face significant resistance around 86K and suggested taking profits at that position.JackYi emphasized that the pullback does not change the overall trend of the bull market; in the early stages of a bull market, there are opportunities everywhere, and high-quality assets will rise in turn. Investors should forget setbacks, filter out noise, and focus on finding long opportunities.